Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture in soft collagenous tissues


The scientific abstract is available at the above link to the article. In laymans terms, we built an imaging system to understand how tissue microstructures - the proteins that give tissues like skin and ligaments their strength - change when tissues are stretched. This microstructural response to loading/stretching is a powerful biological adaption, but can make it somewhat difficult to model tissue behavior. To better understand the changes these protein fibers undergo when loaded, we built a diffuse optical system based on polarized light scattering in tissue, then used the system to examine tissues under mechanical loads.

In Acta Biomaterialia.